The Department of Dermatology is the youngest department in the UP College of Medicine and the Philippine General Hospital. Until its creation as a separate Department which was enacted through a decision by the University of the Philippines Board of Regents in February 3, 2020, the Department has been one of the Divisions of the Department of Medicine. The then Division of Dermatology was created in 1922, with Dr. Perpetuo Gutierrez, the Father of Dermatology in the Philippines, as the first chief.

Because of the vast developments in the field of dermatology globally, the Department has responded to the universal framework for its service and training components and invariably the research endeavors of the Department. Since then, UP PGH Dermatology has fostered several multifaceted dermatologists all over the country who are academically excellent clinicians, educators, researchers, social mobilizers, and administrators.